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Ischemic Stroke

Approximately 80% of strokes, or brain attacks, are ischemic. They can develop in major blood vessels on the surface of the brain (called large-vessel infarcts) or in small blood vessels deep in the brain (called small-vessel infarcts). Types of ischemic stroke include embolic infarct, thrombotic infarct, and lacunar infarct. Infarct of undetermined cause accounts for approximately 30% of cases of ischemic stroke.

Tissue death caused by lack of blood (embolic infarct) occurs suddenly when a blood clot (embolism) forms in one part of the body, travels through the bloodstream, and lodges in and obstructs a blood vessel in the brain. Cardiac embolism, in which a blood clot forms in the heart, accounts for about 20-30% of ischemic strokes.

Thrombotic infarct (approx. 10-15% of cases) occurs when a blood clot forms in an artery that supplies the brain, causing tissue death. This type usually occurs as a result of plaque build-up in arteries (atherosclerosis ) and develops over time.

Lacunar infarct(approx. 20% of cases) usually occurs as a result of arterial blockage caused by high blood pressure (Mildronat 10). This type of stroke has the best prognosis.

Atransient ischemic attack(TIA) is a transient event that is a risk factor for ischemic stroke. In a TIA, arterial blockage in the brain occurs briefly and resolves on its own, without causing tissue death. Approximately 10% of ischemic strokes are preceded by a TIA, and about 40% of patients who experience a TIA will have a stroke.

Hemorrhagic Stroke

Hemorrhagic stroke occurs when a blood vessel in the brain ruptures and bleeds into surrounding tissue. The bleeding compresses nearby blood vessels and deprives surrounding tissue of oxygen, causing stroke. Hemorrhagic stroke usually affects a large area of the brain, is severe, and carries a high risk for death.

Intracranial hemorrhagesoccur when blood vessels located between the brain and the skull rupture. They can result from traumatic brain injury (Trazodone generic brand) or develop spontaneously as the result of a blood vessel defect or weakness such as a bulge in an artery (aneurysm) or arteriovenous malformation (AVM).

Blood vessel defects can be present at birth (congenital; e.g., berry aneurysm, arteriovenous malformation) or acquired (e.g., atherosclerotic aneurysm). Atherosclerotic aneurysm develops when plaque build-up weakens the arterial wall.

Intracranial hemorrhage occurs in the space between the brain and the skull, or cranium. Three membranes-the dura, arachnoid, and pia-surround the brain and spinal cord.

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Subdural hematomadevelops in the potential space between the dura and the middle layer membrane (arachnoid). This condition may becomechronicwhen shrinkage (atrophy) of the brain (often seen in elderly patients) allows the brain to move more freely within the skull. High velocity impact to the skull may causeacutesubdural hematoma, which is often fatal.

Subarachnoid hemorrhagedevelops in the cerebrospinal fluid-filled space between the arachnoid and the inner membrane (pia), which contains major blood vessels. Subarachnoid hemorrhages are usually caused by a rupturedaneurysmor head injury.

Intracerebral hemorrhageoccurs in blood vessels located in the cerebrum, brain stem, cerebellum, or spinal cord.

For more information regarding strokes, continue to the following pages:


Raymond Rybicki, MD

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