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Multiple Sclerosis Signs and Symptoms

The hallmark of multiple sclerosis is unpredictable periods of exacerbation, remission, and progression. Initial symptoms of MS may be brief and mild. The first serious attack usually lasts weeks or months and occurs between the ages of 20 and 40.

The most common early symptoms include sensory abnormalities (e.g., tingling, numbness, itching, tightness, burning, shooting pain in the back and limbs [Lhermitte's sign]) difficulty walking, eye pain, and vision loss.

Symptoms of the disease vary, depending on where the damage occurs, and range from minor physical annoyances to major disabilities. Common symptoms include the following:



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  • Muscle weakness can involve the extremities (arms and legs) on one side of the body (hemiparesis), both legs (paraparesis), or all four extremities (quadraparesis). Muscles in the affected area may tighten (spasticity) and contract spontaneously (spasm or clonus).

    Many people with MS experience fatigue and need to rest and sleep during the day in order to continue their activities. The degree of fatigue may not be related to the severity of other symptoms.

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    This information is for general educational uses only. It may not apply to you and your specific medical needs. This information should not be used in place of a visit, call, consultation with or the advice of your physician or health care professional. Communicate promptly with your physician or other health care professional with any health-related questions or concerns.

    Be sure to follow specific instructions given to you by your physician or health care professional.


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